The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance.

M M Pretorius, J V Gainer, G P Van Guilder, E B Coelho, J M Luther, P Fong, D D Rosenbaum, H A Malave, C Yu, M D Ritchie, D E Vaughan, N J Brown

Journal: Clinical pharmacology and therapeutics 2008;83(1):122-9

PMID: 17522594

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Abstract

We examined the effect of -58 C/T and BE1 +9/-9 polymorphisms in the bradykinin B2 receptor gene on forearm vascular resistance (FVR) before and during intrabrachial artery infusion of the B2 receptor-, endothelium-dependent agonist bradykinin and the endothelium-independent agonist sodium nitroprusside in 228 normotensive subjects. In 166 white Americans, systolic blood pressure (SBP) and pulse pressure were highest in the BE1 +9/+9 group (118+/-2 and 51+/-2 mm Hg, respectively; P<0.05 versus -9/-9 for either), intermediate in the +9/-9 group (114+/-1 and 49+/-1 mm Hg, P<0.05 versus -9/-9 for pulse pressure), and lowest in the -9/-9 group (110+/-2 and 44+/-2 mm Hg). In 62 black Americans, FVR was 25% higher in the BE1 +9/+9 group compared with the BE1 +9/-9 and -9/-9 groups at baseline (P=0.038) or during bradykinin (P=0.03). Increased SBP or vascular resistance may contribute to increased left ventricular mass reported previously in individuals with the BE1+9/+9 genotype.

Address: Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

DOI: 10.1038/sj.clpt.6100250

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MeSH Terms: Adult, Black or African American, Blood Flow Velocity, Blood Pressure, Bradykinin, Dose-Response Relationship, Drug, Female, Forearm, Gene Frequency, Genotype, Humans, Infusions, Intra-Arterial, Male, Nitroprusside, Phenotype, Polymorphism, Genetic, Receptor, Bradykinin B2, Regional Blood Flow, Vascular Resistance, Vasodilator Agents, White People