Active renal secretion of NXY-059, a novel neuroprotectant, is mediated via an organic acid transporter.

Yi-Fang Cheng, Stig Strid, Olof Borgå, Dag Nilsson, Johan Wemer

Journal: Journal of clinical pharmacology 2007;47(7):909-14

PMID: 17585119

Full Text on Wiley View on PubMed

Abstract

Address: AstraZeneca R&D, SE-151 85 Södertälje, Sweden.

DOI: 10.1177/0091270007301803

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https://doi.org/10.1177/0091270007301803

MeSH Terms: Adult, Benzenesulfonates, Cimetidine, Drug Interactions, Female, Glomerular Filtration Rate, Humans, Inulin, Kidney Function Tests, Male, Middle Aged, Neuroprotective Agents, Organic Anion Transporters, Probenecid

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