Endocrine paraneoplastic syndromes in small cell lung carcinoma. Two case reports.

T E Ciuleanu, D Radulescu, S Pripon, D Bunea, L I Radulescu

Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology 2008;12(3):411-4

PMID: 17918299

Abstract

Paraneoplastic syndromes are frequently detected in many small cell lung cancer (SCLC) patients. In the present paper we report 2 cases of patients diagnosed with SCLC, in whom 2 distinct endocrine paraneoplastic syndromes were identified during diagnosis. In the first patient, severe hyponatremia and renal sodium loss with inappropriate antidiuresis was found during routine laboratory tests. Serum antidiuretic hormone (ADH) level was within normal limits, but the atrial natriuretic peptide (ANP) level was elevated. The second case presented with severe hypercalcemia secondary to an excessive parathormone (PTH) secretion. We discuss the 2 cases and review the literature.

Address: 5th Medical Clinic, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania. [email protected]

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https://medlineplus.gov/lungcancer.html

MeSH Terms: Aged, Atrial Natriuretic Factor, Carcinoma, Small Cell, Female, Humans, Hypercalcemia, Hyponatremia, Lung Neoplasms, Male, Paraneoplastic Endocrine Syndromes, Parathyroid Hormone, Vasopressins