OspC phylogenetic analyses support the feasibility of a broadly protective polyvalent chimeric Lyme disease vaccine.

Christopher G Earnhart, Richard T Marconi

Journal: Clinical and vaccine immunology : CVI 2007;14(5):628-34

PMID: 17360854

Abstract

Using available Borrelia outer surface protein C (OspC) sequences, a phylogenetic analysis was undertaken to delineate the number of antigenic domains required for inclusion in a broadly protective, chimeric, OspC-based Lyme disease vaccine. The data indicate that approximately 34 would be required and that an OspC-based vaccinogen is feasible.

Address: Department of Microbiology and Immunology, Center for the Study of Biological Complexity, Medical College of Virginia at Virginia Commonwealth University, Richmond, VA 23298-0678, USA.

DOI: 10.1128/CVI.00409-06

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MeSH Terms: Amino Acid Sequence, Antigens, Bacterial, Bacterial Outer Membrane Proteins, Feasibility Studies, Humans, Lyme Disease, Lyme Disease Vaccines, Molecular Sequence Data, Phylogeny