Increased NKCC1 expression in refractory human epilepsy.

Arjune Sen, Lillian Martinian, Margareta Nikolic, Matthew C Walker, Maria Thom, Sanjay M Sisodiya

Journal: Epilepsy research 2007;74(2-3):220-7

PMID: 17344024

Full Text on Elsevier Science View on PubMed

Abstract

Cation-chloride co-transporters (CCTs), particularly NKCC1, may be important in epileptogenesis. We have performed a detailed histological examination of NKCC1 in large samples of patients with hippocampal sclerosis (HS) or focal cortical dysplasia (FCD), pathologies both commonly associated with pharmacoresistant epilepsy. We consistently found increased immunoreactivity for NKCC1 in HS and FCD, but not in adjacent histologically normal cortex. Our results suggest that NKCC1 might contribute to the pathogenesis or pathophysiology of HS and FCD, thereby potentially offering a new therapeutic target in the treatment of pharmacoresistant epilepsy.

Address: Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom.

DOI: 10.1016/j.eplepsyres.2007.01.004

Link outs

Free resources

Medical:

https://medlineplus.gov/epilepsy.html

Other Literature Sources:

https://www.lens.org/lens/search/patent/list?q=ref...

Subscription / membership required

Full Text Sources:

MeSH Terms: Adolescent, Adult, Aged, Aged, 80 and over, Cerebral Cortex, Child, Child, Preschool, Drug Resistance, Epilepsy, Female, Hippocampus, Humans, Immunohistochemistry, Infant, Male, Middle Aged, Sclerosis, Sodium-Potassium-Chloride Symporters, Solute Carrier Family 12, Member 2