Lipid accumulation product and visceral adiposity index are associated with dietary patterns in adult Americans.

Medicine. 2018;97(19):e0322

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Plain language summary

Centrally stored body fat, or visceral adipose tissue, is associated with a higher risk of cardiovascular disease, metabolic syndrome and certain types of cancer. Higher levels of fats in the blood (triglycerides and cholesterol) have also been associated with the same conditions. This large cross-sectional study (NHANES data set) aimed to examine the association between central body fat and blood lipids, with dietary patterns. Three different dietary patterns were examined: calorie dense diets (diets high in carbohydrates, sugars and fats); nutrient dense diets (diets high in vitamins, minerals and fibre) and healthy fat diets (diets high in mono- and poly-unsaturated fatty acids). The study found that there were significant associations between calorie dense diets and increased central body fat and blood lipids. There was also significant associations between nutrient dense diets and lower levels of central body fat and blood lipids. The results for the healthy fats diet were less conclusive, although they were associated with lower levels of blood lipids.

Abstract

In the present study, we aimed to examine the association between lipid accumulation product (LAP) and visceral adiposity index (VAI) with dietary pattern (DP) in the US adults. Participants of the National Health and Nutrition Examination Survey (NHANES) with data available on dietary intake from 2005 to 2010 were included. DPs were derived by principal component analysis. We applied analysis of covariance and multivariable-adjusted linear regressions accounting for the masked variance and utilizing the proposed weighting methodology. The analytical sample comprised 18,318 participants (mean age = 45.8 years), of whom 48.3% (n = 8607) were men with no age difference by gender (P = .126). The first DP was representative of a diet rich in carbohydrate and sugar, total fat and saturated fatty acid (SFA), high-caloric dieatry pattern; the second DP was highly loaded with vitamins, minerals and fiber (nutrient-dense dietary patten), and the third DP was mainly representative of high dietary polyunsaturated fatty acids (PUFAs) and monounsaturated fatty acids (MUFAs) (healthy fat DP). The adjusted (age, sex, race, physical activity, smoking, C-reactive protein) mean of LAP, VAI and glucose homeostasis indices increased across increasing quarters of the first DP score (all P < .001), while across increasing score of the second DP, the adjusted mean of LAP, VAI, glucose homeostasis indices decreased (all P < .001). Findings were similar in adjusted linear regressions models. Our findings support that affordable measurements, such as VAI and LAP, could be good alternative surrogate markers of visceral fat. They are also significantly related to DPs in same line as with glucose/insulin homeostasis and anthropometric indices.

Functional medicine

Fundamental Clinical Imbalances : Hormonal ; Immune and inflammation
Environmental Inputs : Diet ; Nutrients
Personal Lifestyle Factors : Nutrition
Functional Laboratory Testing : Blood
Bioactive Substances : Insulin ; Triglycerides ; Adiposetissue

Methodological quality

Allocation concealment : Not applicable
Publication Type : Journal Article

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