Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients.

Revista da Associacao Medica Brasileira (1992). 2018;64(2):133-139

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Plain language summary

Ulcerative colitis (UC) is a long term chronic condition where the large intestine becomes inflamed. Though nutritional status is associated with disease severity, the nutritional status of patients during clinical remission (the period when symptoms disappear) is unclear. Therefore, the aim of this study was to assess the association of different nutritional biomarkers of patients with UC during clinical remission. This was a cross sectional study, consisting of 61 subjects where patients were assessed according to the clinical course of disease, body composition and inflammatory profile. The authors concluded that subjects with UC in clinical remission do not present impairment of nutritional status. Despite the limitations in this study, considering that this study is first of its kind, the result of the study warrants further investigation.

Abstract

OBJECTIVE The aim of our study was to assess body composition status and its association with inflammatory profile and extent of intestinal damage in ulcerative colitis patients during clinical remission. METHOD This is a cross-sectional study in which body composition data (phase angle [PhA], fat mass [FM], triceps skin fold thickness [TSFt], mid-arm circumference [MAC], mid-arm muscle circumference [MAMC], adductor pollicis muscle thickness [APMt]), inflammatory profile (C-reactive protein [CRP], a1-acid glycoprotein, erythrocyte sedimentation rate [ESR]) and disease extent were recorded. RESULTS The mean age of the 59 patients was 48.1 years; 53.3% were women. Most patients were in clinical remission (94.9%) and 3.4% was malnourished according to body mass index. PhA was inversely correlated with inflammatory markers such as CRP (R=-0.59; p<0.001) and ESR (R=-0.46; p<0.001) and directly correlated with lean mass: MAMC (R=0.31; p=0.01) and APMt (R=0.47; p<0.001). Lean mass was inversely correlated with non-specific inflammation marker (APMt vs. ESR) and directly correlated with hemoglobin values (MAMC vs. hemoglobin). Logistic regression analysis revealed that body cell mass was associated with disease extent (OR 0.92; 95CI 0.87-0.97; p<0.01). CONCLUSION PhA was inversely correlated with inflammatory markers and directly correlated with lean mass. Acute inflammatory markers were correlated with disease extent. Body cell mass was associated with disease extent.

Functional medicine

Patient Centred Factors : Triggers/Nutritional status
Environmental Inputs : Diet ; Nutrients
Personal Lifestyle Factors : Nutrition
Functional Laboratory Testing : Blood

Methodological quality

Allocation concealment : Not applicable
Publication Type : Journal Article

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